Vinculin anticorps (C-Term)

N° du produit ABIN2788672

L’anticorps Lapin Polyclonal anti-Vinculin a été validé pour WB et IHC. Il convient pour détecter Vinculin dans des échantillons de Humain, Souris, Rat, Lapin, Boeuf (Vache), Cheval, Poisson zèbre (Danio rerio), Chien et Cobaye.

Aperçu rapide pour Vinculin anticorps (C-Term) (ABIN2788672)

Antigène: Vinculin (VCL)

Reactivité: Humain, Souris, Rat, Lapin, Boeuf (Vache), Cheval, Poisson zèbre (Danio rerio), Chien, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Vinculin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Vinculin anticorps

Épitope: C-Term

Séquence: PRPPPPEEKD EEFPEQKAGE VINQPMMMAA RQLHDEARKW SSKGNDIIAA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against VCL. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human VCL

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1066 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Vinculin

Antigène: Vinculin (VCL)

Autre désignation: VCL

Sujet: Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
Alias Symbols: CMD1W, CMH15, MVCL
Protein Interaction Partner: VCL, UBC, TEKT1, SUMO2, ASB7, CTPS1, GINS3, UBFD1, ISOC1, DCPS, ERP44, PDCD10, FERMT2, YWHAQ, TUBB3, PDIA4, STK24, YWHAZ, YWHAH, YWHAG, YWHAE, XPO1, SNRPF, RAP1GDS1, PPP5C, PPP1R2, PFAS, PDHA1, MSN, HSPA9, HSPA5, GSS, SFN, GNAI3, G6PD, EIF5, ECHS1, TBCB,
Protein Size: 1066

Poids moléculaire: 117 kDa

ID gène: 7414

NCBI Accession: NM_003373, NP_003364

UniProt: P18206

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2